Looks like quite a few "big" applications still have issues with Windows Vista OS. "Problems Reports and Solutions" Vista feature just notified me today about Adobe Acrobate Reader constant crashing, and reported that there's a new Reader version available, which "might address these problems". Following the provided link, I downloaded latest version of Acrobate Reader (8.0.0 for Windows Vista) and tried to run it. Here's what I got after initial setup files got unpacked:
Before investigating if this happened due to incorrect UAC setting or other security issue, I simply navigated to the folder where setup files were unpacked to [C:\Users\<User>\AppData\LocalLow\Netopsystems\temp\Adobe Reader 8.0\] and simply copied all the files to a new folder on the c:\ root. After running Setup.exe from there, Acrobat Reader installed correctly. Problem solved.
It's probably too early to really complain about issues like this, since Vista is still quite fresh, and this may only be an installer issue, but they certainly don't make it easy for users wanting to adopt Windows Vista right now.